ApoE^−/− AM^+/+

ApoE^−/− AM^+/+

ApoE^−/− AM^+/−

ApoE^−/− AM^+/+

ApoE^−/− AM^+/+

Ang II 1000 ng/kg/min

(−)

(+)

(+)

(+)

(+)

rhAM ng/kg/hr

0

0

0

300

3000

BW g

28.4 ± 0.3 (4)

27.0 ± 0.5 (17)

27.3 ± 0.3 (27)

28.2 ± 0.4 (11)

27.5 ± 0.6 (16)

SBP mmHg

91 ± 1 (4)

123 ± 3^* (17)

124 ± 3^* (27)

126 ± 7^* (11)

125 ± 6^* (16)

HR /min

580 ± 6 (4)

621 ± 17 (17)

599 ± 13 (27)

610 ± 12 (11)

554 ± 16 (16)